Literature summary for 7.5.2.1 extracted from

Blueschke, B.; Volkmer-Engert, R.; Schneider, E.
Topography of the surface of the signal-transducing protein EIIAGlc that interacts with the MalK subunits of the maltose ATP-binding cassette transporter (MalFGK2) of Salmonella typhimurium (2006), J. Biol. Chem., 281, 12833-12840.

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Inhibitors

Inhibitors	Comment	Organism	Structure
EIIAGlc	when glucose as preferred carbon source is transported, EIIAGlc becomes predominantly unphosphorylated and allosterically inhibits several permeases, including MalFGK2, which possesses a specific binding site in region III of EIIAGlc, in a process termed inducer exclusion involving the N-terminal part of the inhibitor, binding surface, overview	Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + H2O + maltose/out	Salmonella enterica subsp. enterica serovar Typhimurium	-	ADP + phosphate + maltose/in	-	?

Organism

Organism	UniProt	Comment	Textmining
Salmonella enterica subsp. enterica serovar Typhimurium	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O + maltose/out	-	Salmonella enterica subsp. enterica serovar Typhimurium	ADP + phosphate + maltose/in	-	?
ATP + H2O + maltose/out	signal-transducing protein EIIAGlc interacts with the MalK subunits of the maltose ATP-binding cassette transporter	Salmonella enterica subsp. enterica serovar Typhimurium	ADP + phosphate + maltose/in	-	?

Synonyms

Synonyms	Comment	Organism
MalFGK2	-	Salmonella enterica subsp. enterica serovar Typhimurium

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Release 2023.1 (January 2023)